I describe it kind of the same way I describe effective insulin usage - you want it in the background, and once you become aware of it (hypoglycemia or in DNP use - fatigue, big increase in warmth, etc...) you've gone a little too far and should dial it back. I think anything that becomes a hindrance to a training session is a no go, and thats what I found with DNP use during my earlier runs. And running it like I describe now doesn't affect near the same way which I think makes it much more plausible to run during say a prep.