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Active Half-life of Steroids and Esters


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An important consideration when planning a steroid cycle, in particular the timing of dosing to be administered, is the active half-life of the drug being employed. The half-life may be defined as the time (t) the level is half of the starting level of a given compound; at time 2t, the level is a quarter of the starting level, and at time 3t, the level is an eighth of the starting level, and so on. This information is vital in the timing of the dosing when attempting to achieve a more stable blood concentration, which leads to greater overall results and maintenance of gains. Some fluctuations of concentration levels are acceptable, and are also mostly unavoidable, but should be kept to a minimum. This article covers the half-life's of the most commonly used steroids, esters and ancillary compounds.

Oral steroids

DrugActive half-life Anadrol / Anapolan50 (oxymetholone)8 to 9 hours

Anavar (oxandrolone)9 hours

Dianabol (methandrostenolone, methandienone)4.5 to 6 hours

Methyltestosterone 4 days

Winstrol (stanozolol) (tablets or depot taken orally)9 hours

Steroid esters The half-life applies to the ester regardless of hormone attached, for example trenbolone enanthate and primobolan (methenolone enanthate) will act very similarly to testosterone enanthate in terms of release rate. 

DrugActive half-life

Suspension within 1 hour Acetate1 day

Propionate1 day

Phenylpropionate 1-2 days

Butyrate 2-3 days

Valerate 3 days

Hexanoate 3 days

Caproate 4-5 days

Isocaproate 4-5 days

Heptanoate 5-6 days

Enanthate 5-6 days

Octanoate 6-7 days

Cypionate 6-7 days

Nonanoate 7 days

Decanoate 7-8 days

Undeclenate 8-9 days

Undecanoate Approx 20 days

 

Ancillaries

DrugActive half-life

Arimidex 3 days

Clenbuterol 1.5 days

Clomid 5 days

Cytadren 6 hours

Ephedrine 6 hours

T3 10 hours

 

A practical example is if one was to inject 100mg of testosterone propionate and allow blood levels to peak. In approx 36 hours time (half-life duration from the above tables) and providing no other injections had taken place, the level would be reduced to 50mg. Again, a further approx 36 hours down the line and levels would have dropped to 25mg, and the value keeps halving every approx 36 hours. 


 

 

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