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firemetick

Letrozole 2.5mg a day for fertitility?

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After a recent visit with a fertility specialist, he was recommending that i take 2.5mg Letro a day, for 3 month to increase testosterone levels and production of sperm.
I was a bit shocked at the crazy high dose of letro. I asked why not clomid, he mentioned that Canada hasn't stocked it in a few years ( I knew this, so at least he had a good reason)

I mentioned that i had access to clomid and what medication would he prefer if i was to use it, he pondered it, but said he has seen better results with letro.
He mentioned that a canadian university had done a study and showed that letro at 2.5mg a day had increased test levels and sperm production better than clomid.

I expressed my concern about the very large amount of letro per week- (estrogen dropping to zero), and said I would prefer HCG or HMG shots instead.
He said he would start a 2.5mg 3 times a week. the shots would be after 3months, if there has been no positive increase.

Has anyone had Letro as a fertility treatment? If so, any negative side effects?

I'm curious- if letro can increase LH and FSH., making the test to estrogen ratio, test heavy.
Would the increase in LH and FSH be enough /or be similar to the amount of stimulation HCG shots give while on cycle?


thanks for reading, looking forward to any answers..... or guesses.

I look around and could only find 3 study's done on letro in men.
One- done in 2004 with Obese men- it increases test and sperm: http://www.hormonebalance.org/images/documents/de%20Boer%2005%20femara%20obese%20men%20O&M_1313087783.pdf
Two- done in2005 in Singapore with healthy weight men: https://clinicaltrials.gov/ct2/show/NCT02900105
Three, the mention of a university in Montreal, no actual study found just a mix of other peoples results?: https://www.eurekalert.org/pub_releases/2015-03/tes-lia030515.php

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I’ve never heard of this.  Your docs concern is low test?

 

There has to be another option. Letro will completely eliminate ALL estrogen. In my experience using it, I felt absolutely horrible.

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The concern is lower sperm volume and count.. fertility.
Yes my Test is low, average results is between 7.1 and 9.3.
TRT will be something to pursue afterwards but for now fertility is the goal.

From the studies, the subjects estrogen levels didn't drop to zero with letro use.... well, for the ones that took 2.5 mgs a day, it did.
The results had shown that the estrogen levels had dropped, but maintain a low normal-   I assume most subjects had higher conversion rates to begin with because of thier higher BMI.

Letro doesn't allow test to convert to estrogen in all tissues sites, so that's the lowering effect. 
( where as nolvadex doesn't allow estrogen to bind to the receptors in the breast tissue,  and aromasin permanently binds to the enzyme that to converts test to estrogen in circulating hormones.)
Eventually circulating estrogen products will be eliminated,   forcing the testis to attempt to make more test   (to try and convert into estrogen to close the  feedback loop).

So on paper Letro wont eliminate all estrogen from the body.. at least not quickly.
But I will agree with you, as I've used it before when I had a small pea sized lump develop on the right pec during a cycle...... And I felt like crap using Letro.

I was looking to see of anyone else had been given eEtro for fertility.   
  
I feel like I'm the guinea Pig on this one, or at least the one person to seek addition info from a group of people who have had experience with letro use, aside for cancer Pt's and menopausal women.

 

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