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Placebo effect


GameChanger
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Pain. 1983 Jun;16(2):129-43.
Partial antagonism of placebo analgesia by naloxone.
Grevert P, Albert LH, Goldstein A.

 


Thirty subjects were given a placebo (intravenous saline), which was described as a known pain killer, once a week for 3 consecutive weeks. Experimental ischemic arm pain was produced prior to the placebo and again 1 h later. In a double blind procedure, half of the subjects received 10 mg of naloxone after placebo; the remaining subjects received naloxone vehicle. In addition to the placebo session, there were control and naloxone sessions each week to determine the normal changes in pain and the effect of naloxone on the pain, respectively, when no placebo was given. Significant placebo-induced analgesia was demonstrated, and a group of consistent placebo responders was identified. Although naloxone alone had no effect on the experimental pain, naloxone diminished the analgesic effectiveness of the placebo, suggesting that endogenous opioids are involved in producing placebo-induced analgesia.

 

PMID: 6308540

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@GameChanger Many times studies about placebo has been provided and it has been proven to work. The question standing is what happens in the body and in the brain that triggers this effect of false belief? Can the body heal itself on its own? Because it seems very logical. You cant be given a candy (told that it is a pill for headache) and after 30 mins you start to feel a relief. 

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