Jump to content
Sign in to follow this  
musclebeauty

(Ligandrol) LGD 4033 sarm

Recommended Posts

LGD-4033, known also as Ligandrol and Anabolicum, is the strongest orally bioavailable, non-steroidal, selective androgen receptor modulator (SARM) currently on the market.

Popular with athletes, power lifters and body builders for its ability to both bulk and cut, Ligandrol produces steroid-like results without the side effects.

It’s considered an excellent supplement for those looking to recomp: reduce their body fat and increase lean muscle mass.

From a medical perspective, Ligandrol is being studied to treat conditions such as muscle wasting linked with acute and chronic diseases, age-related muscle loss, Osteoporosis and cancer.

Let’s take a closer look…

History Behind LGD 4033

LGD-4033 was originally discovered by Ligand pharmaceuticals and is currently under development by Viking Therapeutics as VK5211.

From the start, LGD-4033 has been anticipated to yield the healing benefits of testosterone with better safety, admissibility and patient acceptance due to tissue-selective mechanism of action and its oral form of administering.

How it Works

Ligandrol works in the same way as other SARM’s: by selectively activating androgen receptors to promote anabolic activity exclusively in muscle and bone.

Studies show [1] that LGD-4033 has a high affinity muscle and bone AR’s rather than prostate, liver or sebaceous glands, which makes it an ideal SARM for building and preserving muscle mass and bone mineral density.

Why YOU Should Take Ligandrol: The Benefits

There are 7 primary benefits that have been observed in both initial studies and user-reported reviews of LGD-4033…

WEEK 5:

That’s when I started to notice a slightly lean body mass gains. My upper body looked fuller, rounder and more muscular. My goal isn’t really to gain size in legs because I naturally have good leg muscles.

WEEK 6:

This is the time when I started to see increases in my lifts and I kept gaining muscle mass.

– WayneLee

https://realpeptide.com/forum/6457-lgd-4033-time-experience.html

  1. LGD-4033 increases lean muscle mass. The clear-cut primary benefit of supplementing with Anabolicum is its ability to increase lean muscle mass without increasing fat when bulking.The Phase 1 trial showed that participants taking 1.0mg of Ligandrol gained on average 2.66lbs (1.21kg) of lean body mass over the 21-day period. This increase was dose-dependent, meaning the more LGD-4033 taken, the more lean muscle mass was created. [1]NB:Recommended dosage is 10mg per day. We do not advocate going higher than this dose.
  1. LGD-4033 may improve strength and stamina. One key study measured participants stair-climbing speed and power as an indicator of muscle strength and endurance. Results from the 21-day study indicated a trend towards dose-related improvement of stair-climbing speed and power thanks to LGD. [1]Real users have noted an increase in muscle strength and stamina while cycling Ligandrol, which correlates with the increase in lean muscle mass seen in studies.

USER REVIEW

I have gained a pretty good amount of strength from this cycle. My core lifts have increased by 20-25%.

– TikTak

https://realpeptide.com/forum/6270-lgd-experience.html

  1. LGD-4033 selectively targets muscle and bone tissue. As a true SARM, LGD targets the AR almost exclusively in muscle and bone tissue, which is why it is being studied to prevent and treat caxechia, sarcopenia, osteoporosis and older individuals recovering from hip fractures.Studies show that, even though there was clear androgenic activity in muscle and bone tissue, the prostate-specific antigen did not change significantly when taking the correct Anabolicum dosage.
  1. LGD-4033 may increase fat loss. LGD has amazing anti-catabolic activity, which means it prevents the breakdown of hard earned muscle. This is why lean body mass has been reported in some users to increase even during a caloric deficit.Ligandrol also indirectly reduces body fat by increasing muscle and bone cells, which are more metabolically expensive to maintain than fat cells. By increasing muscle mass, an increase in the catabolic activity metabolism is seen, which results in easier fat loss.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661116/Many users report stacking LGD-4033 with S4 (Andarine) to support simultaneous bulking and cutting.
  1. LGD-4033 boosts mental well-being. Many users have reported feeling positive, strong and a sense of ‘alpha’ when taking Ligandrol. This state of mental wellbeing and what some have called a slight feeling of ‘aggression’ benefits their lifts in the gym as it improves their competitive streak. Just be sure not to get too competitive and keep your lifts smart and safe.
  1. LGD-4033 may help patients recover from hip fractures. Phase 2 of the clinical trial of Ligandrol is currently underway. Viking Pharmaceuticals noticed that older individuals are at higher risk of suffering a hip fracture and, due to sarcopenia (the natural decline of muscle mass after the age of 30), it’s harder for individuals to both retain and build lean muscle mass.Combined with a hip fracture, and the rate of morbidity due to complications after a fall increases.A supplement such as Ligandrol, which helps increase bone mineral density as well as increase lean muscle mass without the side effects of traditional treatments such as steroids is a promising treatment for an otherwise overlooked population.
  1. LGD-4033 may treat muscle wasting caused by cancer. Anabolicum’s Phase 1 clinical trial showed promising results for building and preserving lean muscle mass in healthy young men, which has lead Viking Pharmaceuticals to investigate how LGD could be used to treat caxechia (muscle wastage) caused by cancer. Trials are currently underway (2016). [2]

The Side Effects of LGD 4033

As with all supplements, some side effects have been noted by both users of Ligandrol and during studies. However, it’s worth noting that side effects of LGD-4033 appear to be not only minimal and reversible, but outweighed by the benefits.

The primary Clinical Trial Phase 1 showed that LGD-4033 was well-tolerated and safe at all doses.

However, some side effects reported by users online include:

  • Headaches
  • Hair growth as well as shedding
  • Nausea
  • Fatigue
  • Muscle Pumps

However, whether these side effects can be attributed to Ligandrol is hard to say, as some users do not purchase their SARMs from reputable sources.

Keep in mind that results and side effects vary by individual, particularly as a minimally-studied, non-FDA approved supplement.

Bottom Line: There have been no serious or long lasting negative effects reported as a result of taking LGD 4033.

And with it’s 24 hour half life, anything you DO experience will go away pretty quickly. I also recommend you limit each cycle to a maximum of 6 weeks and take a full month off before you take it again.

Don’t be stupid, or irresponsible, and always be aware of how your body is responding to it and you’ll be okay.

Does LGD-4033 cause temporary suppression of testosterone?

An interesting side effect of Ligandrol is a dose-dependent suppression of total testosterone and hormone-binding globulin levels. Although Ligandrol increased lean body mass, the study showed testosterone suppression from baseline to day 21 of the three-week study. [1]

However, once LGD-4033 was discontinued, testosterone levels returned to their normal baseline by day 56. A mini-PCT (Post Cycle Therapy) should assist the body in returning to baseline.

USER REVIEW

My ex was tiny like you. I put her on 5mg a day of LGD and she had really good results, her immune system also got way better and she no longer was so underweight…she put on some quality lean mass.

– Stevesmi

https://www.evolutionary.org/forums/anabolic-steroids-peds/sarms-women-54130.html

Dosing Guidelines

Benefits have been documented with dosages as little as 3-10mg every 24 to 36 hrs. Research subjects have been know to tolerate therapy with notable benefits after 2 weeks with improvements continuing for up to 5 months (20 weeks). Note that research recognizes a increase in tolerance after 3 months with benefits continuing to decrease.

Many male users report the upper ideal limit for LGD to be 10mg per day in the morning for twelve weeks.

Although some women have reported using LGD-4033, it has been suggested that it may cause masculinisation lower doses are recommended. Females are advised to stick to an upper limit of 5mg per day.

The chart below is a simple guideline that will work for 99.9% of people:

LGD 4033 Dosing Guidelines LGD 4033 Dosing Guidelines

For Bulking: A protein-rich diet is also necessary as well as higher caloric intake if you plan to beef up by at least 10 lbs.

For Cutting: Use LGD-4033 with SARMS triple pack (GW-501516, S-4 and LGD-4033) to make it more effective as you are aiming to add more size while cutting fat. Suggested dosage is 3-5 mg a day for 8 weeks.

For Recomping: LGD-4033 is best used for recomping. Many users have said that they’ve observed a boost in lean body mass and fat loss. Using it together with other SARMS such as GW-501516 or Cardarine will give you a stronger and better recomp. Suggested dosage is 5-8 mg per day for 8 weeks.

In the studies done on Ligandrol they are using sometimes as little as 1mg and still seeing pronounced muscle gain. This randomized, double-blind study showed that it was safe even up to 22 mg per day for average people.

Post Cycle Therapy (PCT)

Post Cycle Therapy (PCT) is required when taking SARMS to help preserve muscle gains, prevent fat accumulation, maintain mood and motivation, and retain strength in muscles. Cycling also helps to allow hormone levels to return to their natural state in order to prevent unwanted dependency.

Typically, a PCT will last the same duration as supplementation. So if a user supplemented with a hormone for 12 weeks, a PCT of 12 weeks would also be required to bring their hormones back to baseline.

But do I need a PCT when taking SARMs?

Typically, SARMs do not disrupt hormone levels in the body, which means that a traditional PCT is not necessary. However, studies and user reviews show that LGD-4033 temporarily decreases testosterone levels. These levels are quickly reversed when supplementation is stopped, and a mini PCT can help speed up the recovery process.

  • Like 1

Share this post


Link to post
Share on other sites

LGD only at 10mg, I had none to little suppression. Definitely noticed and increase in strength, reps and endurance. 

 

Curious to to see how it would stack with s4 for strength gains.

Share this post


Link to post
Share on other sites
On 9/21/2018 at 7:49 AM, jagr68 said:

LGD only at 10mg, I had none to little suppression. Definitely noticed and increase in strength, reps and endurance. 

 

Curious to to see how it would stack with s4 for strength gains.

Lgd 4033 According to studies on Pub Med will suppress testosterone in correspondence to the amount taken. At 1 mg daily it will suppress Testosterone levels about 80% after 5 weeks! 

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Sign in to follow this  

×
×
  • Create New...