I started it a 0.5 ml a day for 3 days and dose up to 1.0ml /250mcg a day . U could go higher but .. i would jot recommend anything over 1.25 ml it is a pretty high dose .. tho theres is some reports of people running up to 500mcg a day oral .. but .. in my “personal opinion” i think 500 is playing with fire .. 250mcg a day is a good dosage .