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Just curious on the opinions here about LGD vs. Rad for a recomp. Background, 9 years lifting, 26M, 5' 9, 192 lb @ 17% bf, natural for now lol. bloods just done and everything in normal ranges. I am not looking for anything extreme in terms of results. I would say goal is 195 @ 12-14%. Just looking to compare 5mg LGD vs. 10mg of Rad for 8 weeks for a recomp to hit my goals, and dip my toes into the PED world. Thanks in advance to anyone who has info or an opinion

When suspending sarms, a common theme I have seen is using DMSO at 1% of the total mixture. Mainly due to the fact that it’s highly soluble (even allowing the ability to create highly concentrated formulas). But this raises a few questions in mind. 1. How important is the use of DMSO in suspensions due to it’s capabilities of breaching the BBB, and does this cause your chems to become more bio-available? 2. How much of a concern is cytotoxicity with the use of DMSO being administered orally? ”Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are an immune cell or some types of venom, e.g. from the puff adder (Bitis arietans) or brown recluse spider (Loxosceles reclusa).” Most individuals have cited that as long as you stay under %1 DMSO there should be minimal to no cytotoxic elements. But once you reach 1% or greater, cell behavior has been reported. “Our study highlights the capability of DMSO to induce changes in cellular processes in both cardiac and hepatic cells, but more severely, induce alterations in miRNA and epigenetic landscape in the 3D maturing cardiac model. The changes in cellular processes can have consequences for conclusions drawn from cell assays and therefore also in any application of these findings (e.g. false negative drug toxicity conclusions). Furthermore, the extreme changes in miRNA and alterations in the epigenetic landscape may pose a threat, especially for assisted reproductive technology. Genome-wide hypermethylation induced by global deregulation of methylation mechanisms, especially when it affects genes important in development, may have negative consequences directly, later in life or possibly in later generations. Overall, use of DMSO should be avoided where possible. However, for the time being, DMSO is indispensable within biotechnological applications. In these cases, the effects that DMSO may have should be considered and the concentration should be kept as low as possible, because even at low concentrations DMSO is not inert.” https://www.nature.com/articles/s41598-019-40660-0 Smooth-brain in need of big wrinkle-brain knowledge over here.

Hey gang, I promised in @Jetpilot 's thread about liver support aids, that i would post my ongoing findings via bloodwork and PED usage. After "getting off" a deca (300mg week) and sust (500mg week) cycle of 10 weeks, with 4 weeks of nothing but my prescribed trt dosage, i started a rad 140 cycle of 8 weeks. The blood tests i'm providing show a gradual increase of liver enzymes during the course of the rad 140 (oct, nov). Upon stopping the rad 140, and nothing else other than trt ( all of dec), liver enzymes are returning to baseline. So my layman's opinion of rad 140 is that it may be slightly liver toxic to some individuals, although nothing close to the levels achieved by some oral aas (as i had results of anavar after 6 weeks at 550 alt). But like anything your millage may vary. This is nothing but my info to add to the communities data base. Also of note, my white blood cells base line around 8-9, the 11 reading was me fighting a cold. Go figure, the blood tests don't lie!

Hello, Just joined and have many questions. I am 40 and been training consistently for almost 4 years and looking to start a SARMS cycle. Currently 5'11," 168 lbs, and approximately 16% bf. Wanting to add muscle mass at this point and worry about lowering bf later. I was wanting to get hormone panel done to see where I am sitting before starting anything. At this point getting my dr. on board for any kind of testing has not been possible. I would like to know what you fellow Canadians do for hormone testing. Are there mail in Canadian tests or how do you deal with it from a private "pay per service" point of view? I am totally a newbie at all of this so any pointer or advice would be much appreciated! Cheers!

Was super stoked and getting ready to order and run my first SARMS cycle. Looking at running MK-677 and RAD-140. Decided to take a blood test to see where everything was sitting. Currently 40, 186lbs and roughly 16% bf, training for almost 5 years now. It was impossible to get my Doctor to agree to do any testing. Ended up sending away a finger prick sample to letsgetchecked. Waited eagerly for the results and they are as follows. Testosterone 17.50 nmol/L (Normal range 7.6 - 31.4 nmol/L) Sex Hormone Binding Globulin 47.00 nmol/L (Normal range16 - 55 nmol/L) Free Androgen Index 37.20 (Normal range 24 - 104) Prolactin 902.00 mlu/L (Normal range 86 - 324 mIU/L) Oestradiol 83.00 pmol/L (Normal range 0 - 192 pmol/L) Apparently my prolactin is through the roof and I have no idea why. Spoke to a nurse from where I got tested regarding my results. I learned that apparently levels are at their highest during sleep and I took the test at 4:30AM upon waking which cans skew the results. I also was told that strenuous exercise and stress can raise levels as well and I train 5 days a week and have been on an emotional roller coaster lately . The side effects of high levels can be enlarged breast tissue and low testosterone levels, both of which I don't have. Not sure how to interpret the results. Now I don't know what to do, I basically have no support from my doctor and will be read the riot act if I go to him. Feeling really defeated. What should I do? I am totally new to all of this so don't know what next steps might be. Am I correct in assuming that running a SARMS cycle with these results is a bad idea? I appreciate all of your input, great community here, thanks in advance guys!