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What is GW 501516 (Cardarine)? GW 501516 (or Cardarine), is a research chemical developed in the 1990s to prevent and cure tumor formation in the colon, prostate, and breasts. Studies done in the early 2000s have found that GW 501516 and other PPAR agonists have also been able to stop metabolic disorders such as obesity and diabetes through specific gene expressions. As research continued to grow, bodybuilders quickly caught on to GW 501516, calling it “the ultimate endurance enhancing supplement.” Plus, Cardarine’s ability to burn off excess fatty tissue, enhance recovery, and dramatically increase endurance has made this product a staple in every athlete’s cycle and PCT. With no harmful side effects found in the past 20 years, no wonder why GW 501516 has become a legend in the world of sports and athleticism. Let’s take a closer look… How It Works GW501516 is is a PPARδ agonist and NOT a SARM, but does work in very similar ways. In this case, GW 501516 targets the androgen receptors that stimulate glucose uptake and skeletal muscle tissue. Currently, it is being suggested as a potential treatment for obesity by rapidly melting through what’s called “fatty acid oxidation“. Also, Cardarine is said to increase HDL by an average of 79% (good cholesterol) and decrease LDL (bad cholesterol) in current Phase II trials. These help increase your HDL levels from an enhanced expression of the cholesterol transporter ABCA1. The Benefits of GW 501516 The benefits of Cardarine seem to be endless, both in medical science and in the gym. Many studies have been done on GW 501516 showing numerous positive effects during the trial, despite minimum side effects. That is part of the reason why Cardarine has recently become so popular. Below is a list of the most powerful benefits that you could experience while taking a cycle of GW 501516 (compiled from much research and study) The Ultimate Endurance Supplement GW 501516 is literally the best it gets when it comes to endurance, energy, stamina, and performance enhancement of any kind. It is used by elite athletes for a reason, from cyclists to elite bodybuilders. In fact, WADA has even added GW 501516 to their list of banned substances because of its competitive advantage. You can expect insane levels of intensity in the gym, shorter recovery times, and be able to bust through plateaus like never before. Also, the energy you get from Cardarine is not experienced as jittery or anxious. It’s not a stimulant, and you won’t crash hours later. In fact, many users even report feeling an overall sense of well being and calmness. Some of the other benefits include: Rapidly melts fat and NON-catabolic; Provides noticeable results on the first dose; The ability to run for as long as 8-12+ weeks; Is versatile and can be stacked with anything; Can be used while cutting OR bulking; No side effects, liver toxicity, or suppression have been reported; No need for a PCT. Cardarine: The Cure for Obesity? The primary role of GW’s ability to rid the body of unwanted fatty tissue is almost LEGENDARY. The chemical compounds in this particular PPAR agonist functions in the differentiation of adipocytes. Much like growth hormone, GW501516 generates proinflammatory markers in adipose tissue and decreasing the activity of genes involved in lipogenesis. This means that the body is able to block fatty acid chains from forming and being stored as fat. A study from Scientific Reports published in 2015 stated: “GW501516 acts on PPAR beta cells that exclusively use body fat as energy in the same way the body would when going through “starvation mode”. The study is quoted stating: “physiological and pathophysiological functions of PPAR and generated novel strategies to treat metabolic diseases”. The activation of these particular genes in the body has been seen to burn body fat at such an alarming rate that it is being coined “the cure to obesity”. There were absolutely no adverse side effects detected in the last 20 years of study and it was extremely rare to see muscle wasting at any point during the research. Cardarine’s Effects on Muscle Fibers The 2015 study by Wei Chen, Ph.D. and his colleges has also found that dramatic increases in the PPAR gene in slow twitch muscle fibers increases oxygen usage and greatly increases endurance. The enhanced endurance was seen in lab mice with a normal oxygen supply and those with oxygen restrictions which provided significant evidence that GW501516 targets and enhances skeletal muscle endurance and recovery time to a supraphysiological level. Cardarine Results This compound has a long range of proven benefits. The results you can expect while cycling with Cardarine include: • Boost in energy levels: This compound helps you boost your energy levels when you are on a cutting diet. It helps you train longer and harder. You will feel the difference considerably when you are lifting as it improves your strength levels. • Fat loss: Cardarine increases the rate at which stored fat is converted into energy by our body. In this way, you lose fat quickly and look leaner. • Improved recovery: This compound leads to increased oxygen use by increasing the PPAR gene expression located in slow twitch muscle fibres. In this way, it improves your recovery rate and enables you to recover faster and workout more frequently. • Muscle Building: This anabolic compound helps you gain considerable muscle mass. It is a must-have compound if you want to put on some good muscles. It helps in muscle growth by developing existing cells and forming new cells. You should definitely add this to your bodybuilding diet for quick results. GW-501516 Side Effects Not to say that there are none, but in the last 20 years no side effects have been seen by anyone studying the drug. GW501516 has not only been tested in healthy subjects, but also those with simulated “real life” habits (such as drinking alcohol, stimulant narcotics, and the use of tobacco products). It is uncertain if there are long-term ramifications, but no research has been published stating otherwise. This is what makes Cardarine so incredibly popular and usable over long periods of time. In certain studies, there have even been signs showing the reversal of diabetes, obesity, Dyslipidemia and many other diseases. Liver Damage In contrast to popular belief, GW501516 doesn’t promote damage to liver cells. The chemical has actually been known to promote healthy liver function and faster healing properties to the skin and muscle tissue. In essence, you will not heal rapidly like Wolverine from the X Men movies, but you will shorten your recovery time from scratches, blisters, and injured muscles by a significant amount. Cardarine Cancer There have been many forum comments expressing the concerns of GW501516 and it’s relationship to cancer and tumor development. The hypothesis for this controversy stems from GW’s ability to improve Angiogenesis in the body at an extremely high rate and the rate of cancer growth in the colons of lab mice. This is a common occurrence among endurance athletes and children going through adolescence. Scientists had speculated that if there were tumor cells active in the body, that they would be especially susceptible to angiogenesis and cause the tumor to grow at a much faster rate. Since 2004 many experiments have been done to prove this hypothesis, but so far, all of them have been largely unsuccessful. A study published in 2004 by the American Association of Cancer Research stated that PPAR agonists have: …Shown to have no effect on the proliferation of colorectal cancer cells and “…under normal culture conditions, PPAR activation has no effect on cell growth”. Keep in mind that this study was done in rats given amounts of 400 mg a day and was abused and ran for hundreds of weeks to top it all off. Time and time again this study has been refuted and shown to be deeply flawed and inaccurate. In a 2008 experiment done on human breast cancer and colon cancer cells, not only did the PPAR agonist GW 501516 prove to be safe for use, it has proven to inhibit cancer cell growth. The National Institute of Health has confirmed without a reasonable doubt that GW 501516 inhibits a multitude of cancers in human cells. Over a decade of research studies on human PPAR beta (the primary target of GW) has only proven a decrease in cancer cells with extended use (up to two years). The confusion for these previous allegations of cancer growth was from results published in 1996 and have long since been abandoned due to new clinical research. The chemical compound has been dosed in human PPAR for a number of years and has only provided positive results on cancer treatments, liver function, and metabolic efficiency. In all of the human studies done so far, there were no noticeable side effects at all while running GW. Check out some of the studies and resources on GW 501516 for more info: http://www.ncbi.nlm.nih.gov/pubmed/22814748 http://diabetes.diabetesjournals.org/content/57/2/332.long http://atvb.ahajournals.org/content/27/2/359.long

Hi everyone nice guys from Kratos graciously sent me a few items to try out Madol and a few oils I haven’t used the oils yet but I did use the Madol at 20mg it a real kick in the ass I don’t imagine training without it now , tabs are well pressed not chalky or dusty none broken the dose seems spot on, communication was fast shipping even faster, rep was great to deal with, I will continue the review as I pin the oils.

Learn everything you need to know before starting the Intermittent Fasting plan including it's history, guidelines & components, & all the science behind it. Intermittent fasting is a dietary philosophythat either involves long periods of fasting followed by short windows of feasting or 24 hours of fasting followed by 24 hours of feasting (this is known as alternate day fasting). There are several variations of intermittent fasting with the most popular fasting protocol being a 16 hour fast followed by an 8 hour feasting window. The basis of intermittent fasting hinges on a few key ideas: Maximizing the time your body spends oxidizing fatMinimizing overall insulin load to the systemImproved energy levelsIncreased longevity. Recently several key studies have been carried out to examine how these claims stack up to the research and the results have been quite interesting. History Behind Intermittent Fasting Intermittent fasting as it is currently understood and practice is often believed to have begun with Martin Berkhan as he is largely responsible for the widespread adoption of the diet amongst body building and figure competition circles. However, the idea of fasting as a dietary principle dates back much further than that. The ancient Greek physician Hippocrates wrote, “To eat when you are sick, is to feed your illness”. Another ancient Greek writer and historian Plutarch is also credited with penning “Instead of using medicine, better fast today”. In more recent times one of our founding fathers, Benjamin Franklin, stated, “The best of all medicines is resting and fasting”. Thus, while the recent popularization of intermittent fasting has brought this approach to main stream health and fitness culture, the idea of fasting is as ancient as the dawn of civilized man. General Overview of Components & Main Principles of Intermittent Fasting Intermittent fasting is a dietary philosophy that utilizes fasting and feasting periods. There are several variations of intermittent fasting with the most popular fasting protocol being a 16 hour fast followed by an 8 hour feasting window. Intermittent fasting does not by design prescribe specific calorie allotments, macronutrient ratios, or provide a list of good or bad foods to eat and is generally not restrictive of any foods. Meal Timing/Frequency Unlike many other dietary frameworks or plans, intermittent fasting relies almost solely on meal timing and meal frequency. As typically thought of, intermittent fasting usually adopts a 16 hour fasting window, followed by an 8 hour feasting window. Most people will consume 1-2 very large meals during the feasting window, although one can consume several small meals throughout this time. Other fasting approaches, such as the alternative day fast employs a 24 hour fast, followed by a full 24 hours of feasting. Restrictions/Limitations Aside from the timing restrictions and limitations, there are no hard and fast food restrictions of limitations. This is often interpreted as an “anything goes” during the feasting window. However, in practice, the people who achieve the best results using intermittent fasting typically apply another dietary framework (such as IIFYM or flexible dieting) to give them some structure to their food intake during the feasting window. Does it Include Phases? Intermitting fasting does not include any phases in its dietary protocol, although some people will go through fasting cycles where they go long periods of adhering to the fasting protocols and then periods of normal eating. Who is it Best Suited For? Intermittent fasting is best suited for people who have busy schedules and would prefer to lump their eating into 1-2 meals a day rather than spreading them throughout the day. Fasting can also be excellent for people learning to manage hunger cues and retraining their eating habits. Intermittent fasting is also an excellent way to help people control calories as often times shortening the amount of time one eats during the day can reduce overall calories. How Easy is it to Follow? Intermittent fasting is easy to follow in that it does not limit or restrict food, allows one to eat without tightly tracking calories, and will not place a burden on your social life (i.e. not being able to go out to dinner and order something on the menu). It also can make life much easier as there is less time spent cooking, eating, and cleaning up. It can be difficult for some people who enjoy the process of cooking and eating; people who struggle learning to manage hunger during the early phases of adopting the diet may also find it difficult to follow. Mainstream Belief Behind Diet The mainstream belief behind intermittent fasting is that it unlocks aspects of our evolution as human beings and conveys some health and weight loss benefits when compared to our traditional 3 meals per day approach. Several of the beliefs underlying intermittent fasting are: Maximizing the time your body spends oxidizing fatMinimizing overall insulin load to the systemImproved energy levels,Increased longevity.Scientific Studies and Interpretation of Data There are quite a few studies that delve into the benefits of intermittent fasting as a tool to promote fat loss. As mentioned prior, the ideal of fasting to promote health benefits has been around since ancient civilization. Today, many of the general speculations regarding the general health benefits of fasting still ring true, however whether or not this has more to do with caloric restriction is still up for debate. Below we will outline some of the studies that have been conducted that lay out these benefits in an unbiased platform. Fat Loss Benefits One of the major claims of intermittent fasting is that it is an excellent tool for fat loss. There have been several studies that have examined the role of meal frequency in fat loss, including things like alternate day fasting and even the intermittent fasting protocol. For a long while these studies were brushed off by social media and fitness forums as they were not truly studies of the specific intermittent fasting protocol; however, recently one study was done that followed the traditional 16/8 fasting/feasting protocol as prescribed by traditional intermittent fasting protocols1. In this study, the group following the intermittent fasting protocol did lose about 3.5 pounds more fat than the normal dieting group; however, this also occurred concurrently with lower calorie intake than the normal diet group so it is likely the greater fat loss was due to lower calorie intake. One of the more interesting notes about this study, as mentioned by Greg Nuckols is that, “Testosterone and IGF-1 levels decreased, levels of several pro-inflammatory cytokines decreased, cortisol levels increased, insulin and blood glucose levels decreased, triglyceride levels decreased, T3 levels decreased and RER decreased slightly. Those are all things you’d expect to see in a calorie deficit. And while it’s true that the IF group was in a calorie deficit, it was a very small one (less than 10% below maintenance) – probably not a large enough deficit to explain those effects. On the whole, this study makes it seem that IF “tricks” your body into thinking you’re dieting, even if you’re at (or at least close to) caloric maintenance, in a manner that’s generally consistent with improved health and longevity”2. Muscle Building Benefits When you look closely at the fasting literature it appears that intermittent fasting does not appear to convey any additional benefits to muscle building when calories are held equal. That being said, periods of fasting may improve the quality of muscle tissue by increasing its cellular cleaning processes (e.g. autophagy and heat shock protein response)3,4,5. However, this research is currently preliminary and is mostly speculation at this point. Overall Health Benefits Of all the areas of research on fasting, the effects of fasting on overall health and longevity perhaps the most interesting. Several studies in animal models have shown that periods of fasting increase lifespan and improve several metabolic parameters as these animals age6,7. Perhaps the best known phenomena of fasting is increases in autophagy, a cellular “cleaning process”. There is some good animal evidence to also suggest that fasting may increase longevity; however, the data in humans is short term and long term data is not available, so much of this is still speculation8. Conclusion Intermittent fasting offers a food-flexible approach to dieting and may have some unique metabolic benefits for health and longevity. From a fat loss perspective, intermittent fasting can be an excellent tool, mainly due to controlling calorie intakes. Intermittent fasting can be used in its widely known format of a 16 hour fast followed by an 8 hour feasting window; the alternate day fasting approach with a 24 hour fast followed by a 24 hour feast. Intermittent fasting is easy to follow in that it does not limit or restrict food, allows one to eat without tightly tracking calories. ReferencesEffects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained malesThe “Leangains” Intermittent Fasting Study Is Finally HereAMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during AgingAutophagy is required to maintain muscle mass.Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal MuscleApparent Prolongation of the Life Span of Rats by Intermittent FastingFasting: Molecular Mechanisms and Clinical ApplicationsEffect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals A Randomized Controlled Trial

Mind over matter! I do one 24 hour fast per week. Brutal but very rewarding

I don’t know what’s with this drug, but 3 weeks ago my bp was borderline bad. Now on just 15mgs a day I was 122/70 down from my average of135-155 over 85-90. I have been doing more cardio recently, but that couldn’t entirely account for this. I have never ever been this low and my hr went down for 75-85 average to 65 as well.

Once a day? Damn, that's pretty hardcore. Have to give you complete respect, I honestly don't think I could do that.

I love intermittent fasting been doing the omad fasting eat once a day and now so much leaner plus tons more energy too.. also your GH production is active when you're not eating so therefore if you eat four or five meals a day you're shutting your own natural growth hormone off all the times that you're eating cant beat that......

Kicking ass here wow am I amazed at this journey. So I'm now 189 and getting leaner by the day it feels I will weigh in again in a few weeks. As of now though I am a ecstatic Last night shot 1/2 cc t400 1/2cc eq and 2 mls primo no pain no stiffness zero nada Fucking stellar and am amazed will post up a pic

I am stubborn and like to go.old school dnp is not my jam.

Not yesterday, but here's one...